As you saw with Peyton Manning and the Indianapolis Colts, Tom Brady and the New England Patriots or Aaron Donald with the Los Angeles Rams, it sometimes takes just one NFL draft pick to forever alter a franchise for the better.

On the more pessimistic side, one simple draft mistake can doom a team and set them back for many years. Just look at the worst franchises of the 21st century. The Detroit Lions, Las Vegas Raiders and Jacksonville Jaguars drafted far more busts than quality players with their early-round picks.

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There's no going back and changing the past, but history could have been much different (in a good way) for these five NFL teams if they drafted a future superstar over a bust.

10 Bust: Jalen Reagor

It's only been two years, but the 2020 NFL Draft looks like it will be one of the best ever as far as wide receivers are concerned. So far, however, Jalen Reagor hasn't contributed much in Philadelphia.

The Eagles selected Reagor 21st overall in 2020. Through two seasons, he has just 64 receptions for 695 yards and three touchdowns. With DeVonta Smith and A.J. Brown now leading the receiving group, it's hard to envision Reagor ever panning out in Philly at this point.

9 Should Have Been Selected: Justin Jefferson

Following the Reagor pick, the Minnesota Vikings took LSU wideout Justin Jefferson at No. 22 overall. Needless to say, the Vikings have been rewarded very well.

Jefferson is arguably a top-five receiver in the game now, with a pair of Pro Bowl nods and 1,000-yard seasons already on his résumé. Could you imagine if the Eagles had Jefferson, Smith and/or Brown leading their offense? This was a big-time miss by GM Howie Roseman, to say the least.

8 Bust: Clelin Ferrell

The No. 4 pick of the 2019 Draft will certainly go down as one of the greatest busts in Las Vegas Raiders history.

Ferrell was considered a major reach at the time. Sure enough, the Raiders haven't gotten much out of the pick. Ferrell has started just 26 games over three seasons, recording eight sacks and nine pass defenses. Ferrell played just 24 percent of the team's defensive snaps in the games he suited up for last year.

7 Should Have Been Selected: Devin White

Now, the Raiders had the right idea when they drafted Ferrell. The team was greatly lacking in playmakers on the front seven, after all. They just chose the wrong player.

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Right after Ferrell, the Tampa Bay Buccaneers selected do-it-all linebacker Devin White with the No. 5 pick. White has gone on to become one of the game's most dynamic and explosive game-wreckers on defense. There is no way the Bucs win Super Bowl 55 without his all-time great postseason dominance.

Now, just imagine if the Raiders had White leading the front seven alongside Maxx Crosby and 2022 free agent pickup Chandler Jones?

6 Bust: Solomon Thomas

The San Francisco 49ers traded the No. 2 pick of the 2017 to the Chicago Bears, who selected Mitch Trubisky. With the third overall selection, the 49ers selected Stanford defensive end Solomon Thomas.

San Fran got very little out of Thomas. In five seasons, he posted just six sacks and zero forced fumbles. They passed on a plethora of future stars, including Patrick Mahomes, Marshon Lattimore, Tre'Davious White, Christian McCaffrey and Marlon Humphrey, among others.

5 Should Have Been Selected: T.J. Watt

J.J.'s younger brother has emerged as one of the NFL's top-five defensive players. It's simply hard to comprehend how 29 players went before him in that year's draft.

Even without Thomas, the 49ers have a potent pass rush led by Nick Bosa, Fred Warner and Arik Armstead. But this unit would have reached another stratosphere if they had landed a player of Watt's caliber instead of Thomas. Perhaps Watt could've made a difference in the 49ers' heartbreaking Super Bowl 54 loss.

4 Bust: Sam Darnold

The Indianapolis Colts already had Andrew Luck, so they weren't inclined to take a signal-caller in the quarterback-heavy 2018 Draft despite holding the No. 3 pick. Indianaplis GM Chris Ballard traded that pick to the New York Jets, who went on to select USC quarterback Sam Darnold.

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Darnold can't take all the blame for flopping in New York. The team didn't supply him with enough talent, and Adam Gase was simply not suited for a head coaching position. At the same time, the Jets expected a talented player like Darnold to mask some of the many problems on the team. But was out of Gotham after three seasons.

3 Should Have Been Selected: Josh Allen

The Bills traded up via the Tampa Bay Buccaneers to select Josh Allen with the No. 7 pick. Fast-forward four years later, and he's already on pace to become the greatest Buffalo player of all-time.

Allen is easily a top-five quarterback in the game now. His slick arm, pinpoint accuracy and dynamic two-way play has made him a human highlight reel. He has led Buffalo to three straight playoff berths, an AFC Championship appearance and two AFC East division titles.

What more can we say? If only the Jets had a time machine so they could go back to 2018 and take Allen over Darnold.

2 Bust: Mitchell Trubisky

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As previously mentioned, the Bears traded up one spot, so they could select Trubisky with the No. 2 pick in 2017. They had the right position in mind, but the Bears took the wrong player.

Trubisky wasn't horrible by any means. But he failed to elevate his game when the Bears needed it most, despite a stellar supporting cast led by David Montgomery, Allen Robinson, Tarik Cohen and Jimmy Graham. Trubisky never topped 3,223 passing yards or 24 touchdown passes in a season during his four-year tenure with the Bears.

1 Should Have Been Selected: Patrick Mahomes

In defense of the Bears, nobody at the time really thought that Mahomes would play his way into the conversation for the best NFL player of his era. Yet here we are five years later.

Kansas City actually traded up via Buffalo to get Mahomes at No. 10 overall. Through his first four NFL seasons, Mahomes has led the Chiefs to four AFC West division titles, two Super Bowl appearances, one Lombardi Trophy and four AFC Championship Games. With 18,991 passing yards and 151 touchdown passes in 63 NFL games, what more can we say? Bears fans really aren't going to get over this one for a long time.